Dhori Virus: Infection In Mice The Pathological Process Of Severe Myxovirus Infection.

Once intranasal, body covering, or intraperitoneal infection with Dhori virus (DHOV), adult mice developed a sudden and uniformly fatal sickness with several of the clinical and pathologic findings seen in mice infected with H5N1 extremely morbific craniate flu a deadly disease. 

Histopathologic decisions in the lungs of DHOV-infected mice consisted of inflammation, hemorrhage, and thickening of the interstitium and also the alveolar septa and alveolar puffiness. 

Extra-pulmonary findings enclosed hepatocellular gangrene and steatosis, widespread severe fibrinoid gangrene in humour organs, marked white cell loss and karyorrhexis, and neuronic degeneration in the brain. 

Similar general histopathologic findings are reported within the few fatal human H5N1 cases examined at autopsy. due to the connection of DHOV to the flu viruses, it is level two standing, and its similar pathology in mice, the DHOV-mouse model might provide an affordable, comparatively safe, and realistic animal model for studies on the pathological process and management of H5N1 infection.