Agranulocytosis: A Condition In Absolute Neutrophil Count.
It is a condition in which the absolute neutrophil count is less than 100 neutrophils. Normally, at least 1500 neutrophils per microliter of blood. For granulocyte counts it between 100 and 1500 per microliter of blood, the term granulocytopenia or neutropenia is used.
Agranulocytosis is very important and also can be a Life-Threatening order. If it is not used, it can lead to death, most often through septicemia bacterial infection of the blood.
Cause include:
- Chemotherapy to treat cancer.
- The use of some prescription drugs, particularly drugs, particularly certain antibiotics, and anti-psychotic and anti-thyroid medication.
- Bone marrow abortion disorders such as aplastic anaemia.
- Other medical conditions, such as some autoimmune diseases or tumours.
- The congenital form of agranulocytosis is Kossmann disease.
Symptoms of agranulocytosis may include:
- Sores in the throat, mouth, or gastrointestinal tract.
- blood pressure in which may cause by life-threatening drop, which may cause lightheadedness or weakness.
- Chronic infections of the throat, gums, or skin.
- Chills
- Fever
The specific mechanisms behind the development of this complication have not been fully elucidated, although the hypotheses include immune-mediated neutropenia and direct toxicity of bone marrow. The development of antineutrophil antibodies, and more rarely ANCA supports the immune origin of agranulocytosis by drugs.
Other mechanisms possibly involved are suppression of granulocytes production, complement-dependent cytotoxicity, and agglutination of neutrophils by antineutrophil antibodies.
Treatment of agranulocytosis involves immediate stopping of drug and using G-CSF since it shortens the duration of neutropenia and implies fewer risks of infections and fatal complications.