Hutchinson-Gilford Syndrome: Characterized by The Rapid Expression In Childhood.
Interested children typically look normal at birth and in beginning infancy, but then grow more casually than other children and do not obtain weight at the conventional rate failure to thrive. They develop a characteristic facial appearance, including a thin nose, prominent eyes with a broken tip,
This Syndrome is a genetic situation characterized by dramatic start in childhood.
Interested children typically look normal at birth and in beginning infancy, but then grow more casually than other children and do not obtain weight at the conventional rate failure to thrive. They develop a characteristic facial appearance, including a thin nose, prominent eyes with a broken tip, thin lips, protruding ears and, a small chin.
This syndrome also causes hair loss alopecia, joint abnormalities, aged-looking skin, and a loss of fat under the skin called subcutaneous fat. This situation does not affect intellectual development or the improvement of motor skills such as sitting, walking, and standing.
Mutations in the LMNA gene creat Hutchinson-Gilford progeria syndrome. The LMNA gene provides instruction for making a protein called Lamin A. This protein plays a main role in determining the pattern of the nucleus within cells.
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It is an indispensable scaffolding component of the nuclear envelope, which is the membrane that surrounds the nucleus. The mutation that causes Hutchinson-Gilford progeria syndrome results in the generation of an abnormal variant of the lamin A protein.
The altered protein makes the nuclear envelope progressively and unstable damaged the nucleus, making cells more likely to die precipitately. Researchers are managing to define how these changes lead to the characteristic features of Hutchinson-Gilford progeria syndrome.
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